3H-Nicotine, 3H-Flunitrazepam, and 3H-Cocaine Incorporation Into Melanin: A Model for the Examination of Drug-Melanin Interactions
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منابع مشابه
Deposition of [3H]cocaine, [3H]nicotine, and [3H]flunitrazepam in mouse hair melanosomes after systemic administration.
Microautoradiography was employed to show that association of drugs from the serum directly with forming hair pigment is a primary pathway of deposition into the hair. After systemic administration of [3H]flunitrazepam, [3H]nicotine, and [3H]cocaine, association of all three drugs with melanin in the forming hair was observed within minutes of dosage. Sebum was determined to be an insignificant...
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In order to determine if functional changes in N-methyl-D-aspartate receptors and GABAA receptors play a role in the remarkable anoxia tolerance of freshwater turtle brain, we used autoradiographic techniques to assay [3H]MK-801 and [3H]flunitrazepam binding in turtle forebrain after turtles had been subjected to anoxia for 2 or 6 h. The effects of glutamate, glycine, competitive N-methyl-D-asp...
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Protein-calorie malnutrition or fasting leads to a readily detectable decrease in the rate of body growth and cellular proliferation, particularly in young animals (32, 33) . In contrast, disorders in cell and organ function have generally been more difficult to demonstrate, perhaps partly due to limitations in methodology (8, 16, 22) . Mitochondria are the primary energy source for the work of...
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Previous EM autoradiographic studies have shown that injection of [3H]proline ([3H]Pro) into the cat dorsal column nuclei (DCN) results in heavy labeling of macroglia but negligible labeling of DCN neurons. [3H]Leucine ([3H]Leu), in contrast, was extensively incorporated into both neurons and glia. We now report preliminary assessment of differences in molecular labeling patterns produced by th...
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Mice were given 4 injections of [H]thymidine at 2-hourly intervals and killed at times varying from 1 h to 12 days after the last injection. Autoradiographs of spleen, oesophagus and heart were prepared by the stripping-film technique and exposed for 21, 189 and 367 days. Groups of lymphoid cells surrounding trabeculae were heavily labelled, the decline in grain count suggesting division of the...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 2001
ISSN: 0146-4760,1945-2403
DOI: 10.1093/jat/25.7.607